Answer:
critical obstacle to developing effective medications to prevent and/or treat alcohol use disorders is the lack of specific knowledge regarding the plethora of molecular targets and mechanisms underlying alcohol (ethanol) action in the brain. To identify the role of individual receptor subunits in ethanol-induced behaviors, we developed a novel class of ultra-sensitive ethanol receptors (USERs) that allow activation of a single receptor subunit population sensitized to extremely low ethanol concentrations. USERs were created by mutating as few as four residues in the extracellular loop 2 region of glycine receptors (GlyRs) or γ-aminobutyric acid type A receptors (GABAARs), which are implicated in causing many behavioral effects linked to ethanol abuse. USERs, expressed in Xenopus oocytes and tested using two-electrode voltage clamp, demonstrated an increase in ethanol sensitivity of 100-fold over wild-type receptors by significantly decreasing the threshold and increasing the magnitude of ethanol response, without altering general receptor properties including sensitivity to the neurosteroid, allopregnanolone. These profound changes in ethanol sensitivity were observed across multiple subunits of GlyRs and GABAARs. Collectively, our studies set the stage for using USER technology in genetically engineered animals as a unique tool to increase understanding of the neurobiological basis of the behavioral effects of ethanol.
Explanation:
make me as brain liest
Colonial soldiers won the Siege of Boston, even though they
Answer:
even though they were were poorly trained compared to the British
Explanation:
:)
Which were two pull factors that drove many European imigrants to America in both the 1600s and the early 18003?
O major famines and poverty
O available land and economic opportunity
O religious persecution and unfair treatment
O available jobs and political problems
Answer:
Correct answer is religious persecution and unfair treatment.
Explanation:
The third option is a correct one as especially in early 1600s, but also later in early 1800s people were having unfair treatment by the ruling class, especially the Puritans who were banished from the authorities.
First option is wrong because the best example of this is the immigration of Irish due to their famine.
Second option is also not correct as it was not their main reasons, although they did gain new land.
Fourth option is also not correct as this was not a reason especially in 1600s as they weren't sure what awaits them in the New World.
Answer:
yeah no its c
Explanation:
good luck, its on the unit test and cumulative ^^
The state governments had more power than the national government TRUE OR FALSE
Answer:
FALSE
Explanation:
What was the original name of Israel?
Palestine
Jericho
Acre
Canaan
Answer:
The answer is Cannan.
Answer: Acre
Explanation:
Best answer is Acre. I remember learning about this in church this summer!
Who supported the constitution anti-federalists or federalists
Answer:
Federalists
Explanation:
Federalists were the first political party of the United States. They supported the Constitution, and attempted to convince the States to ratify the document.
What is the name of the empresario who was given permission by Mexico to,settle the nacogdoches area?
A. Green Dewitt
B. Steven F. Austin
C. Martin De Leon
Answer:
c.
Hayden Edwards
Explanation:
In 1825, Edwards received a land grant from the Mexican government, allowing him to settle families in East Texas. His grant included the city of Nacogdoches, and Edwards soon angered many of the previous settlers.
Which battle proved to the French that the Americans could win the Revolutionary War? (5 points)
Group of answer choices
Cowpens
Yorktown
Saratoga
Trenton
Answer:
The battle of Saratoga.
The Battle proved to the French that the Americans could win the Revolutionary War is the Battle of Saratoga. Hence, Option C is correct.
What do you know about the Battle of Saratoga?The Revolutionary War was changed by the Battle of Saratoga. The American army's victory over the superior British army raised national spirits, boosted the dream of independence, and helped to win the war's necessary foreign backing.
Nine miles south of the town of Saratoga, on the fields of upstate New York, the Saratoga battle took place. General John Burgoyne was attempting to invade New England from Canada in accordance with British plans in order to cut off New England from the rest of the United States.
Hence, The Battle proved to the French that the Americans could win the Revolutionary War is the Battle of Saratoga. Option C is correct.
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can somebody help with #40 and #41 ?
Answer:
For #40 i think it is A and for #41 i think it is D
Which state is farther north,
North Dakota or Maine?
Maine, while sometimes appearing to be the northernmost of the 48 contiguous states, actually ranks sixth after Washington, Idaho, Montana, North Dakota, and Minnesota
North Dakota is farther north than Maine.
Maine is sometimes mistaken for the northernmost state in the contiguous United States, however, this is not the case. The settlement of Estcourt Station, located at 47 degrees 12 minutes north latitude, is Maine's northernmost point.
North Dakota's northernmost point is Pembina Point, which is located at 49 degrees 00 minutes north latitude. This indicates that North Dakota is one degree and 48 minutes north of Maine.
Hence, North Dakota is the farther north state of the two. The northernmost point of North Dakota is about 1 degree north of the 48th parallel, while the northernmost point of Maine is about 2 degrees south of the 48th parallel.
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All of the following became major products of colonial Texas except:
A.corn
B.cotton
C.sugar cane
D.Oil
Answer:
possibly corn
Answer:
D. Oil
Explanation:
In my notes on edg it said:
The Growth of Texas
Due to the lure of cheap land and the convenience of the empresario system, many people began to settle in Texas. Trade was expanded between settlements, farms and plantations produced more goods, and cattle ranching became a major industry Cotton, corn, and sugar cane became major productions
what are 20 facts about the scientific revolution?
Answer:
Scientific Revolution, drastic change in scientific thought that took place during the 16th and 17th centuries. A new view of nature emerged during the Scientific Revolution, replacing the Greek view that had dominated science for almost 2,000 years. Science became an autonomous discipline, distinct from both philosophy and technology, and it came to be regarded as having utilitarian goals. By the end of this period, it may not be too much to say that science had replaced Christianity as the focal point of European civilization. Out of the ferment of the Renaissance and Reformation there arose a new view of science, bringing about the following transformations: the reeducation of common sense in favour of abstract reasoning; the substitution of a quantitative for a qualitative view of nature; the view of nature as a machine rather than as an organism; the development of an experimental, scientific method that sought definite answers to certain limited questions couched in the framework of specific theories; and the acceptance of new criteria for explanation, stressing the “how” rather than the “why” that had characterized the Aristotelian search for final causes.
Copernican system
Explanation:
So I understand what it means, but I don’t know how to put it in words. Can somebody describe to me what “civil rights” are?
Answer:
What are civil rights? Civil rights are an essential component of democracy. They're guarantees of equal social opportunities and protection under the law, regardless of race, religion, or other characteristics. Examples are the rights to vote, to a fair trial, to government services, and to a public education.
Explanation:
When did the French Revolution take place?
Answer:
The French Revolution lasted from 1789 until 1799.
Explanation:
The three main goals of the French Revolution were liberty, equality, and fraternity. Liberty meant that everyone had all of their natural rights and freedoms. Equality meant that everyone would be equal in the eyes of the government. Fraternity meant that everyone would get along and respect each other's rights.
Answer:
hey maya im boarddd
Explanation:
Identify two reasons people may have migrated out of Africa between 60,000 and 70,000 years ago.
Answer:
Climate change, Availability of resources
Explanation:
1. Soon enough when the climate on the planet started to become more arid and become too hot, so humans started to migrate from Africa.
2. People started to move away to the places where resources were available.
2. Read all four quotes. Answer the question
The statements below are from the 1776 Virginia Declaration of Rights
1) That in all capital or criminal prosecutions a man bath a right to demand
evidence in his favor, and to a speedy trial by an impartial jury...
2) That the legislative, executive, and judiciary department shall be separate
and distinct.
3) That the freedom of the press is one of the great bulwarks of liberty, and
can never be restrained...
4) That a well regulated militia, composed of the body of the people, trained
to arms is the proper, natural, and safe defense of a free state
Source: PaMic Domain US National Archives and Records Administration
Which statement reflects the Enlightenment ideas of government as expressed by Montesquieu?
Choose an answer and explain why you chose that answer. Using complete
sentences.
The correct answer is number 2) That the legislative, executive, and judiciary departments shall be separate and distinct.
The statement reflects the Enlightenment ideas of government as expressed by Montesquieu is the following: "That the legislative, executive, and judiciary department shall be separate and distinct."
During the Enlightenment, different thinkers and philosophers developed new and interesting concepts about government.
That was the case of Baron of Montesquiou, who established that the legislative, executive, and judiciary departments shall be separate and distinct in order to function well. This concept influenced the founding fathers of the United States when they decided about the new form of government that the US needed. That was part of the debates between Federalists and Antifederalists.
Other prominent thinkers and philosophers during the Enlightenment period were Voltaire, Jean-Jaques Rousseau, ThomasHobbes, and John Locke.
Explain how Abraham and Moses impacted the founding of Judaism.
Answer:
Abraham began to build Judaism when he chose to believe in just one God, the Creator and Almighty, then his son Isaac had Jacob who later had 12 sons that formed the 12 tribes which were Israel and all of them followed Abraham beliefs, Judaism. Later after 400 years of slavery in Egipt, Moses was used by God to get them free and lead them to the promised land.
Explanation:
True or False/ King Cotton diplomacy was a key part of the Southern Strategy.
How did the organization of business change in the 1800s?
Answer:
During the late nineteenth century, large corporations that employed thousands of workers formed. These companies became known as Big Businesses. ... At most, these firms might be able to dominate local markets, but they played only a minimal role in the national economy. Following the Civil War, Big Business changed
Who negotiated a treaty to resolve the continuing problems with the British?
Vice President John Adams
Secretary of State Thomas Jefferson
Chief Justice John Jay
Secretary of the Treasury Alexander Hamilton
Explain the extent to which “republican motherhood” influenced the lives of women during and after the Revolutionary war.
Answer:
Women who ran households in the absence of men became more assertive. Abigail Adams, wife of John, became an early advocate of women's rights when she prompted her husband to "Remember the Ladies" when drawing up a new government.
Explanation:
Hope this helped :>
Can someone help me plz
Answer:
The answer is D. Trenton
Explanation:
#5 Please help!!!!!!
Answer:
B
Explanation:
Answer:
The answer is option B
Explanation:
Please mark as brainliest
PLEASE HELP
Which of the following is NOT a reason given for the establishment of the Constitution?
A.) To provide for the common defense
B.) To form a more perfect union
C.) To promote the general welfare
D.) To establish justice
E.) To insure foreign tranquility
F.) To secure the blessings of liberty
Insure foreign tranquility is not a reason given for the establishment of the Constitution. Option E is correct.
What is the significance of constitution?A constitution is vital because it guarantees that individuals who make decisions on behalf of the people do so fairly. It also outlines how those in positions of power can be held accountable to the people they serve.
It determines citizens relationships with governments. It safeguards and guarantees all people fundamental rights. It specifies how the Government will be elected, as well as who will have the authority and responsibility to make important decisions.
The constitution provides for the public's common defense. It makes the union more complete, promotes the general welfare, establishes justice, and secures the benefits of liberty.
Therefore, The foundation of the Constitution was not done to ensure foreign tranquility. So, option E is correct.
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What was the new policy or goal of the dawes act ?
Answer:
to assimilate Native Americans into mainstream US society by annihilating their cultural and social traditions.
Explanation:
hope this was helpful!!
Describe how science, technology, and knowledge aided in transoceanic travel and trade.
Answer:
European technological developments in cartography and navigation built on previous knowledge developed in the classical, Islamic and Asian worlds, and included the production of new tools. (such as astrolabe or revised maps), innovations in ship designs. (such as caravels) and an improved understanding of global wind and currents patterns, all of which made transoceanic travel and trade possibl
Answer:
European developments in cartography and navigation was a scientific way that aided in transoceanic travel and trade. Through innovative discoveries and findings from other worlds such as the classical, Islamic, and Asian worlds, the Europeans were able to improve and make travel and trade possible. They adapted, improved, and synthesized technologies and knowledge developed in other worlds to advance their own. For example, the astrolabe that originated from Greek and Islam was introduced to Europeans, who used it and altered it to make their own versions, such as the mariner's astrolabe which helped sailors determine their latitude using the stars.
European technological developments were built upon new findings of the world as well as past developments from classical cultures. Using knowledge developed in the classical, Islamic, and Asian worlds, the production of new tools such as the innovative ship designs such as the caravel. Due to its lighter weight and greater speed, the caravel was immensely popular among sailors. It adopted the lateen sail, making ships highly maneuverable and using the wind to sail. The Spanish altered the caravel to make the Spanish galleon, a large multi-deck ship that was the primary vessel of the Spanish Treasure Fleet and could carry large amounts of cargo. These new innovations boosted transoceanic travel.
Knowledge, or rather the European research and study of past knowledge, has also been a crucial factor aiding transoceanic travel and trade. Europeans borrowed the knowledge of Greek cartographers such as Ptolemy, using their calculations and incorporating it into the development of new world maps. They also integrated math processes and principles to calculate distance and resemble geographic features. This new method of map-making revolutionized cartography since merchants could use revised maps to plot new routes and use their experience to further update later maps.
Additionally, an improved understanding of global wind and ocean current patterns allowed sailors to navigate the sea more efficiently and safer. Portuguese sailors noted that using their knowledge of trade winds can benefit them if they used them for sailing rather than going against them. This spread of knowledge on bettering experiences and knowledge aided trade and transoceanic travel.
Additional Notes:
Hope this helps! Be sure to reword it and just use this as a guide :D
2. How might the establishment of a Judenrat have given Jews in the ghetto a false sense of security?
Answer:
Explanation:
becuse germans that were not jews were included
can someone help me with this math plz
Answer:
132.45
Explanation:
Is this the Gaby that went to Thompson?
Answer:
The answer is $132.45
Explanation:
We need to find how much money Richard has at the end of the week.
First, we need to subtract $25.37 from $57.34 since $25.37 is how much Rich spent on groceries.
1. $57.34 - $25.37 = $31.97
Next, we need to subtract $50.00 from $31.97, because that is how much his credit card bill was.
2. $31.97 - $50.00 = $-18.03
Now, $-18.03 means that Rich is $18.03 in debt.
Proceeding from that step, we now need to add $163.75 to Rich's debt of $18.03. This is how much he will deposit into his bank.
3. $-18.03 + $163.75 = $145.72
So now his debt of $18.03 has turned into a deposit of $145.72.
Finally we need to subtract $13.27 from $145.72 since that's how much money Rich's gas cost.
4. $145.72 - $13.27 = $132.45
So at the end of the week, Rich has an account balance of $132.45.
- Saiko Intelli
I will brainlist, please help
Answer: Okay so I think that it is the first one, but I am not entirely sure.
Explanation: So sorry if it is wrong...
What was the opulence of the ancient kingdom of Ghana?
Answer:
between the 9 th and 11th centuries C.E the kingdom of ghana was so rich that its dogs wore golden collars, and it's hores, which were adnorned with silken rope halters, slept on plush carpets. based on animal luxuries alone, it's is no wonder that foreigners touted ghanas kings as the richest man in the world.
Following the Compromise of 1877, poll taxes, literacy tests and the Grandfather Clause were used to… *
Answer:
All those things were used as voter suppression to keep blacks from voting. At the time, the south was Democratic and they knew that the black people would vote Republican since Abraham Lincoln was a Republican.
Explanation:
Sounds kind of like the Democrats of today... LOL
